Wednesday, November 30, 2011

Long lines at polls as Egypt holds landmark vote

Shaking off years of political apathy, Egyptians turned out in long lines at voting stations Monday in the first parliamentary elections since Hosni Mubarak's ouster, a giant step toward what they hope will be a democracy after decades of dictatorship.

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Some voters brought their children along, saying they wanted them to learn how to exercise their rights in a democracy as they cast ballots in what promises to be the fairest and cleanest election in Egypt in living memory. With fears of violence largely unrealized, the biggest complaint was the hours of standing in long, slow-moving lines.

"If you have waited for 30 years, can't you wait now for another hour?" an army officer yelled at hundreds of restless women at one polling center in Cairo.

After the dramatic, 18-day uprising that ended Mubarak's three decades of authoritarian rule, many had looked forward to this day in expectation of a celebration of freedom. But Mubarak's fall on Feb. 11 was followed by nearly 10 months of military rule, divisions and violence and when election day finally arrived, the mood was markedly different. People were eager to at last cast a free vote, but daunted by all the uncertainty over what happens next.

US woman: I was sexually assaulted by Egypt police

"I never voted because I was never sure it was for real," said Shahira Ahmed, 45, waiting with her husband and daughter with around 500 other people at a Cairo polling station. "This time, I hope it is, but I am not positive."

Even as they vote, Egyptians are sharply polarized and confused over the nation's direction.

On one level, the election will be a strong indicator of whether Egypt is heading toward Islamism or secularism. The Muslim Brotherhood, Egypt's largest and best organized group, along with other Islamists are expected to dominate in the vote. Many liberals, leftists, Christians and pious Muslims who oppose mixing religion and politics went expressly to the polls to try to stop them or at least reduce their victory.

The U.S. and its close ally Israel, which has a long-standing peace treaty with Egypt, worry that stronger Brotherhood influence could end Egypt's role as a major moderating influence in Middle East politics.

Also weighing heavily on voters' mind was whether this election can really set Egypt on a path of democracy while it is still under military rule. Only 10 days before the elections, major protests erupted around the country demanding the ruling generals accused of bungling the transition step aside and hand power immediately to a civilian authority.

Another concern is that the parliament that emerges may have little relevance because the military is sharply limiting its powers, and it may only serve for several months.

The Egyptian election is the fruit of the Arab Spring revolts that have swept the region over the past year, toppling several authoritarian regimes. In Tunisia and Morocco, Islamic parties have come out winners in elections the past month, but if the much larger Egypt does the same, it could have an even greater impact.

Even before voting began at 8 a.m., people stood in lines stretching several hundred yards outside many polling stations in Cairo, suggesting a respectable turnout. Under heavy security from police and soldiers, segregated lines of men and women grew, snaking around blocks and prompting authorities to extend voting by two hours.

Many said they were voting for the first time. For decades, few Egyptians bothered to cast ballots because nearly every election was rigged, whether by bribery, ballot box stuffing or intimidation by police at the polls. Turnout was often in the single digits.

"I am voting for freedom. We lived in slavery. Now we want justice in freedom," said 50-year-old Iris Nawar at a polling station in Maadi, a Cairo suburb.

Video: Egypt holds 1st elections since uprising (on this page)

"We are afraid of the Muslim Brotherhood. But we lived for 30 years under Mubarak, we will live with them, too," said Nawar, a first-time voter.

Waiting for hours, people joked, squabbled, and bought sandwiches from delivery men taking advantage of an eager, captive market.

Under a heavy rain in the Mediterranean coastal city of Alexandria, a women's line displayed Egypt's religious spectrum ? Christians and Muslims with their hair loose, others in conservative headscarves, still others blanketed in the most radical garb, the black robes that cover a woman's entire body, leaving only the eyes exposed. At a nearby station, one soldier shouted through a megaphone, "Choose freely, choose whomever you want to vote for."

The Brotherhood entered the campaign armed with a powerful network of activists around the country and years of experience in political activity. Even though it was banned under Mubarak's regime, its politicians sat in parliament as independents. Also running is the even more conservative Salafi movement, which advocates a hard-line Saudi Arabian-style interpretation of Islam. While the Brotherhood shows at times a willingness to play politics and compromise in its ideology, many Salafis make no bones about saying democracy must take a back seat to Islamic law.

In contrast, the secular and liberal youth groups that ousted Mubarak failed to capitalize on their astonishing triumph to effectively contest the election. They largely had to create all-new parties from scratch, most of which are not widely known among the public and were plagued by divisions through the past months.

"The Muslim Brotherhood are the people who have stood by us when times were difficult," said Ragya el-Said, a 47-year-old lawyer in Alexandria, a stronghold for the Brotherhood. "We have a lot of confidence in them."

But the Brotherhood faces still opposition. Even some who favor more religion in public life are suspicious of their motives, and the large Christian minority ? about 10 percent of the population of around 85 million ? deeply fear rising Islamism.

Slideshow: Protests continue in Egypt (on this page)

"I'm a Muslim but won't vote for any Islamist party because their views are too narrow," said Eman el-Khoury, 53, as she looked disapprovingly at Brotherhood activists handing out campaign leaflets near an Alexandria polling station, a violation of election rules. "How can we change this country when at an opportunity for change, we make the same dirty mistakes."

For many of those who did not want to vote for the Brotherhood or other Islamists, the alternative was not clear.

"I don't know any of the parties or who I'm voting for," Teresa Sobhi, a Christian voter in the southern city of Assiut, said. "I'll vote for the first names I see I guess."

The election is a long and unwieldy process. It will be held in stages divided up by provinces. Voting for 498-seat People's Assembly, parliament's lower chamber, will last until January, then elections for the 390-member upper house will drag on until March.

Each round lasts two days. Some voters said they feared vote rigging or ballot stuffing because the ballot boxes would be left at polling stations overnight.

Monday and Tuesday's vote will take place in nine provinces whose residents account for 24 million of Egypt's estimated 85 million people.

The ballots are a confusing mix of party lists that will gain seats according to proportions of votes and individual candidates ? who will have to enter run-off votes after each round if no one gets 50 percent of the first-round vote. Mixed in are candidates labeled as "farmer" or "worker" who must gain a certain number of seats, a holdover for socialist days that Mubarak's regime manipulated to get in cronies.

Moreover, there are significant questions over how relevant the new parliament will even be. The ruling military council of generals, led by Field Marshal Hussein Tantawi, insists it will maintain considerable powers after the election. It will put together the government and is trying to keep extensive control over the creation of an assembly to write a new constitution, a task that originally was seen as mainly in the parliament's hands.

Video: Freed American student: ?It was very scary? (on this page)

The protesters who took to Cairo's Tahrir Square and other cities since Nov. 19 in rallies recalling the uprising that ousted Mubarak on Feb. 11 demand the generals surrender power immediately to a civilian government.

Some hoped their vote would help eventually push the generals out.

"We are fed up with the military," said Salah Radwan, waiting outside a polling center in Cairo's middle-class Abdeen neighborhood. "They should go to protect our borders and leave us to rule ourselves. Even if we don't get it right this time, we will get it right next time."

On Monday morning in Tahrir, a relatively small crowd of a few thousand kept the round-the-clock protests going. Clashes during the protests left more than 40 dead and had heightened fears of violence at polling stations.

Turnout among the estimated 50 million voters will play a key role. A higher turnout could water down the showing of the Brotherhood, because its core of supporters are the most likely to vote.

If there are heavy numbers of voters, that could also give legitimacy to a vote that the military insisted go ahead despite the recent turmoil.

A referendum on constitutional amendments in March had a turnout of 40 percent ? anything lower than that could be a sign that skepticism over the process is high.

The Brotherhood, which used to run its candidates as independents because of the official ban on the group, made its strongest showing in elections in 2005, when it won 20 percent of parliament's seats. Its leaders have predicted that in this vote it could win up to 40 or 50 percent.

? 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/45459377/ns/world_news-mideast_n_africa/

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Angry Pakistan to boycott Afghanistan talks (Reuters)

KABUL/LAHORE, Pakistan (Reuters) ? Pakistan pulled out of an international conference on the future of Afghanistan on Tuesday, its latest angry riposte after a cross-border attack by NATO that killed 24 of its soldiers and plunged the conflict-plagued region deeper into crisis.

Islamabad's decision to boycott next week's meeting in Bonn, Germany, on securing peace after NATO combat troops leave Afghanistan in 2014 means a key player that can lean on Taliban militants to join the process will be absent.

"The cabinet reaffirmed Pakistan's support for stability and peace in Afghanistan and the importance of an Afghan-led, Afghan-owned process of reconciliation," the government said in a statement.

"Pakistan looks forward to the success of this conference but in view of developments and prevailing circumstances has decided not to participate in the conference."

The move will not be a major setback to the process of planning Afghanistan's future as few tangible results were expected at Bonn, despite the attendance of Secretary of State Hillary Clinton and other government ministers.

Bonn was organized with the expectation that Washington and Kabul would have pinned down by then what their strategic relationship would look like after the departure of foreign combat troops, but talks on this have dragged on inconclusively on no agreement has yet been struck.

Indeed, Pakistan's decision to pull out over last weekend's border attack was seen by some diplomats as an over-reaction because the conference involves not just Washington but the wider international community, including China, Japan, Iran and the European Union.

A senior diplomat in Kabul dubbed it "a pretty huge miscalculation."

"The agenda of Bonn does not depend on Pakistan, nor does its success depend on Pakistan," a senior British foreign office official told reporters. "But it would be better for Pakistan if she were there. There is a slight risk of the Pakistanis disenfranchising themselves."

Pentagon spokesman George Little said that despite the announcement from Islamabad, U.S. officials "certainly hope that Pakistan will attend."

"We believe it's critical for countries in the region and who have interests in Afghanistan attend," he told reporters.

PEACE TALKS?

The decision to pull out of Bonn appears to be the latest attempt by Pakistan to put pressure on Washington and NATO following what Pakistan says was an unprovoked attack on two combat outposts on the border with Afghanistan last Saturday.

The Pakistani statement also reaffirmed a decision to review cooperation with the United States and NATO.

"Despite Pakistan's continued efforts to play a positive role for stability and peace in countering terrorism and militancy in the region, the sacrifices of the nation have not been recognized," the statement said.

The incident also bodes poorly for Pakistan's future cooperation with Afghanistan's peace process, which is seen as crucial by some because it might nudge the Taliban and the al Qaeda-linked Haqqani network to the negotiating table.

"Pakistan has an important leverage of facilitating, cooperating, trying to put pressure on the Taliban, trying to put pressure on the Haqqani group," said retired Pakistani general and defense analyst Talat Masood.

"And if Pakistan is absent, there is a possibility that all these levers that Pakistan can exercise to facilitate the withdrawal will not be available."

Pakistan has a long history of ties to militant groups in Afghanistan so it is uniquely positioned to help bring about a peace settlement, a top foreign policy and security goal for the U.S. administration.

Fury at the cross-border incident showed no signs of abating. Pakistani cable television operators threatened to block Western news channels they say are anti-Pakistani.

"We want to send them a strong message to stop this. If they don't stop this, then it is our right to stop them," Khalid Arain, president of the All Pakistan Cable Operators Association (APCOA) said in a live media conference. The BBC was the focus of criticism.

Sadiq Lakhani, vice chairman of the APCOA, said the BBC would be blocked by midnight local time (1900 GMT).

WHAT REALLY HAPPENED?

NATO described the killings as a "tragic, unintended incident". Separate NATO and U.S. probes are underway.

A Western official and an Afghan security official who requested anonymity said NATO troops were responding to fire from across the border at the time of the incident.

Pakistan disagrees, saying the attack lasted two hours despite warnings from the outposts, and has reserved the right to retaliate.

Both the Western and Pakistani explanations are possibly correct: that a retaliatory attack by NATO troops took a tragic, mistaken turn in harsh terrain where differentiating friend from foe can be difficult.

U.S. military officials said the investigation was ongoing and it wasn't clear when the results would be made public.

"No one at this point has the complete narrative on what happened,' Little told reporters. "We need to be patient."

An Afghan Taliban commander, Mullah Samiullah Rahmani, said the group had not been engaged in fighting NATO or Afghan forces in the area at the time, although Taliban fighters control several Afghan villages near the border with Pakistan.

A similar cross-border incident on September 30, 2010, which killed two Pakistani service personnel, led to the closure of one of NATO's supply routes through Pakistan for 10 days.

The supply lines have again been shut down, leaving hundreds of supply trucks stranded in a security challenge for Pakistan.

"We are at full strength and on high alert on the highways because of the stranded trucks," said a police official in Muzaffargarh town who asked not to be identified. "We are very worried about the situation. We cannot guarantee security."

NATO supply trucks are often attacked by bandits and militants.

Earlier on Tuesday, protests against NATO spread across Pakistan. At least 300 members of the student wing of the Pakistan Tehreek-i-Insaaf, the political party of former cricketer Imran Khan, blocked a road in Lahore and chanted slogans for about 90 minutes.

In Multan in southern Punjab, about as many again chanted "Death to America" and burned U.S. and NATO flags.

"This attack is an attack on all of Pakistan," said Tariq Naimullah, one of the protesters. "Pakistan will become a graveyard for NATO."

(Additional reporting by Chris Allbritton, Augustine Anthony, Zeeshan Haider and Qasim Nauman in ISLAMABAD, Asim Tanveer in MULTAN, Jan Harvey in KABUL, Myra MacDonald in LONDON, Missy Ryan in WASHINGTON; Writing by Chris Allbritton; Editing by John Chalmers and Paul Tait)

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/nm/20111129/wl_nm/us_pakistan_nato_conference

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Acer VP: 'We're never gonna give netbooks up, let them down, run around and desert them'

Acer's no stranger to netbooks: it knows the rules and so does vice president Scott Lin, who has said that a full commitment's what he's thinking of. It comes in the wake of Samsung running around and deserting baby-laptops for ultrabooks, but Acer's never gonna say goodbye. Well-off westerners might be obsessed with slates, but emerging markets like China, India and Indonesia prefer the cheaper units. The company's plan is simple -- what it doesn't make in profit on individual units, it'll make back in the sheer volume of units sold. Last quarter Acer sold one point seven million of the things, comfortably ahead of second-placed ASUS and third placed Samsung -- the latter decided it wasn't gonna play the game anymore.

Continue reading Acer VP: 'We're never gonna give netbooks up, let them down, run around and desert them'

Acer VP: 'We're never gonna give netbooks up, let them down, run around and desert them' originally appeared on Engadget on Tue, 29 Nov 2011 11:11:00 EDT. Please see our terms for use of feeds.

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Kennedy Center taps pianist Moran as jazz adviser (AP)

WASHINGTON ? The Kennedy Center for the Performing Arts on Tuesday tapped 36-year-old pianist and composer Jason Moran to be its artistic adviser for jazz, a post held by acclaimed musician Billy Taylor until his death last December at 89.

The generational handoff wasn't planned in advance but makes sense as jazz evolves, musical directors at the Washington, D.C. center said. Moran, who lives in New York City and teaches at the New England Conservatory in Boston, won a $500,000 "genius grant" last year from the MacArthur Foundation and is known for mixing visuals and other media with his productions.

Moran told The Associated Press he thinks often about how to place jazz in a 2011 context.

"It's not like it was in 1959, and it's definitely not like it was in 1939, and it's not like it was in 1900," he said. "Things have changed. Jazz it at a different place right now. So where does it fit, and with whom does it echo?"

As artistic adviser for the next three years, Moran will help select artists and develop one of the nation's largest jazz programs. The Kennedy Center presents more than 30 performances each year, including concerts in its own jazz club and performances broadcast on National Public Radio.

But hiring a young, daring adviser won't necessarily bring big changes to the program, said Kevin Struthers, the center's jazz director. He said Moran can "swing with the best of them" but also take the genre in a different direction.

"I think we have selected someone who is firmly rooted in the traditions of the music," Struthers said. "Jazz is not to be put on a shelf as a museum piece. It is important that we pay homage to the past, and I think Jason does that through his music, but he puts it in a contemporary setting."

Taylor, a pianist and composer who played with luminaries such as Dizzy Gillespie and Miles Davis, became an ardent jazz advocate through radio, TV and his Jazzmobile arts venue that visited urban neighborhoods. He profiled musicians for CBS' "Sunday Morning" show ? winning an Emmy Award in 1983 for a piece on Quincy Jones ? and assumed the Kennedy Center post in 1994.

Moran said he considers Taylor a mentor because he always had advice and critiques to offer. He began learning from Taylor at age 16 during a master class at his high school. The young pianist performed at the Kennedy Center for the first time in 1998 through a program to identify young talent.

"At a certain point, my generation has to stand up to continue to hand down the information that has been given to us," he said. "Billy has been a person who bridged the gap between jazz and the American public ... So that's the thing I want to continue to model in whatever I do."

___

Kennedy Center: http://www.kennedy-center.org

___

Follow Brett Zongker at http://twitter.com/DCArtBeat

Source: http://us.rd.yahoo.com/dailynews/rss/music/*http%3A//news.yahoo.com/s/ap/20111129/ap_en_mu/us_music_jason_moran

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UCLA researchers engineer blood stem cells to fight melanoma

UCLA researchers engineer blood stem cells to fight melanoma [ Back to EurekAlert! ] Public release date: 28-Nov-2011
[ | E-mail | Share Share ]

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences

Researchers from UCLA's cancer and stem cell centers have demonstrated for the first time that blood stem cells can be engineered to create cancer-killing T-cells that seek out and attack a human melanoma. The researchers believe this approach could be useful in 40 percent of Caucasians with this malignancy.

Done in mouse models, the study serves as first proof-of-principle that blood stem cells, which make every cell type found in blood, can be genetically altered in a living organism to create an army of melanoma-fighting T-cells, said Jerome Zack, study senior author and a scientist with UCLA's Jonsson Comprehensive Cancer Center and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.

"We knew from previous studies that we could generate engineered T-cells, but would they work to fight cancer in a relevant model of human disease, such as melanoma," said Zack, a professor of medicine and microbiology, immunology, and molecular genetics in Life Sciences. "We found with this study that they do work in a human model to fight cancer, and it's a pretty exciting finding."

The study appears Nov. 28, 2011 in the early online edition of the peer-reviewed journal Proceedings of the National Academy of Sciences.

Researchers used a T-cell receptor from a cancer patient cloned by other scientists that seeks out an antigen expressed by this type of melanoma. They then genetically engineered the human blood stem cells by importing genes for the T-cell receptor into the stem cell nucleus using a viral vehicle. The genes integrate with the cell DNA and are permanently incorporated into the blood stem cells, theoretically enabling them to produce melanoma-fighting cells indefinitely and when needed, said Dimitrios N. Vatakis, study first author and an assistant researcher in Zack's lab.

"The nice thing about this approach is a few engineered stem cells can turn into an army of T-cells that will respond to the presence of this melanoma antigen," Vatakis said. "These cells can exist in the periphery of the blood and if they detect the melanoma antigen, they can replicate to fight the cancer."

In the study, the engineered blood stem cells were placed into human thymus tissue that had been implanted in the mice, allowing Zack and his team to study the human immune system reaction to melanoma in a living organism. Over time, about six weeks, the engineered blood stem cells developed into a large population of mature, melanoma-specific T-cells that were able to target the right cancer cells.

The mice were then implanted with two types of melanoma, one that expressed the antigen complex that attracts the engineered T-cells and one tumor that did not. The engineered cells specifically went after the antigen-expressing melanoma, leaving the control tumor alone, Zack said.

The study included nine mice. In four animals, the antigen-expressing melanomas were completely eliminated. In the other five mice, the antigen-expressing melanomas decreased in size, Zack said, an impressive finding.

Response was assessed not only by measuring physical tumor size, but by monitoring the cancer's metabolic activity using Positron Emission Tomography (PET), which measures how much energy the cancer is "eating" to drive its growth.

"We were very happy to see that four tumors were completely gone and the rest had regressed, both by measuring their size and actually seeing their metabolic activity through PET," Zack said.

This approach to immune system engineering has intriguing implications, Zack said. T-cells can be engineered to fight disease, but their function is not long-lasting in most cases. More engineered T-cells ultimately are needed to sustain a response. This approach engineers the cells that give rise to the T-cells, so "fresh" cancer-killing cells could be generated when needed, perhaps protecting against cancer recurrence later.

Going forward, the team would like to test this approach in clinical trials. One possible approach would be to engineer both the peripheral T-cells and the blood stem cells that give rise to T-cells. The peripheral T-cells would serve as the front line cancer fighters, while the blood stem cells are creating a second wave of warriors to take up the battle as the front line T-cells are losing function.

Zack said he hopes this engineered immunity approach will translate to other cancers as well, including breast and prostate cancers.

###

The four-year study was funded in part by the National Institutes of Health, the California Institute for Regenerative Medicine, the Caltech-UCLA Joint Center for Translational Medicine, UCLA Center for AIDS Research and the UCLA AIDS Institute.

UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2011, the Jonsson Cancer Center was named among the top 10 cancer centers nationwide by U.S. News & World Report, a ranking it has held for 11 of the last 12 years. For more information on the Jonsson Cancer Center, visit our website at http://www.cancer.ucla.edu.

The stem cell center was launched in 2005 with a UCLA commitment of $20 million over five years. A $20 million gift from the Eli and Edythe Broad Foundation in 2007 resulted in the renaming of the center. With more than 200 members, the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research is committed to a multi-disciplinary, integrated collaboration of scientific, academic and medical disciplines for the purpose of understanding adult and human embryonic stem cells. The center supports innovation, excellence and the highest ethical standards focused on stem cell research with the intent of facilitating basic scientific inquiry directed towards future clinical applications to treat disease. The center is a collaboration of the David Geffen School of Medicine, UCLA's Jonsson Cancer Center, the Henry Samueli School of Engineering and Applied Science and the UCLA College of Letters and Science. To learn more about the center, visit our web site at http://www.stemcell.ucla.edu. To learn more about the center, visit our web site at http://www.stemcell.ucla.edu.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


UCLA researchers engineer blood stem cells to fight melanoma [ Back to EurekAlert! ] Public release date: 28-Nov-2011
[ | E-mail | Share Share ]

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences

Researchers from UCLA's cancer and stem cell centers have demonstrated for the first time that blood stem cells can be engineered to create cancer-killing T-cells that seek out and attack a human melanoma. The researchers believe this approach could be useful in 40 percent of Caucasians with this malignancy.

Done in mouse models, the study serves as first proof-of-principle that blood stem cells, which make every cell type found in blood, can be genetically altered in a living organism to create an army of melanoma-fighting T-cells, said Jerome Zack, study senior author and a scientist with UCLA's Jonsson Comprehensive Cancer Center and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.

"We knew from previous studies that we could generate engineered T-cells, but would they work to fight cancer in a relevant model of human disease, such as melanoma," said Zack, a professor of medicine and microbiology, immunology, and molecular genetics in Life Sciences. "We found with this study that they do work in a human model to fight cancer, and it's a pretty exciting finding."

The study appears Nov. 28, 2011 in the early online edition of the peer-reviewed journal Proceedings of the National Academy of Sciences.

Researchers used a T-cell receptor from a cancer patient cloned by other scientists that seeks out an antigen expressed by this type of melanoma. They then genetically engineered the human blood stem cells by importing genes for the T-cell receptor into the stem cell nucleus using a viral vehicle. The genes integrate with the cell DNA and are permanently incorporated into the blood stem cells, theoretically enabling them to produce melanoma-fighting cells indefinitely and when needed, said Dimitrios N. Vatakis, study first author and an assistant researcher in Zack's lab.

"The nice thing about this approach is a few engineered stem cells can turn into an army of T-cells that will respond to the presence of this melanoma antigen," Vatakis said. "These cells can exist in the periphery of the blood and if they detect the melanoma antigen, they can replicate to fight the cancer."

In the study, the engineered blood stem cells were placed into human thymus tissue that had been implanted in the mice, allowing Zack and his team to study the human immune system reaction to melanoma in a living organism. Over time, about six weeks, the engineered blood stem cells developed into a large population of mature, melanoma-specific T-cells that were able to target the right cancer cells.

The mice were then implanted with two types of melanoma, one that expressed the antigen complex that attracts the engineered T-cells and one tumor that did not. The engineered cells specifically went after the antigen-expressing melanoma, leaving the control tumor alone, Zack said.

The study included nine mice. In four animals, the antigen-expressing melanomas were completely eliminated. In the other five mice, the antigen-expressing melanomas decreased in size, Zack said, an impressive finding.

Response was assessed not only by measuring physical tumor size, but by monitoring the cancer's metabolic activity using Positron Emission Tomography (PET), which measures how much energy the cancer is "eating" to drive its growth.

"We were very happy to see that four tumors were completely gone and the rest had regressed, both by measuring their size and actually seeing their metabolic activity through PET," Zack said.

This approach to immune system engineering has intriguing implications, Zack said. T-cells can be engineered to fight disease, but their function is not long-lasting in most cases. More engineered T-cells ultimately are needed to sustain a response. This approach engineers the cells that give rise to the T-cells, so "fresh" cancer-killing cells could be generated when needed, perhaps protecting against cancer recurrence later.

Going forward, the team would like to test this approach in clinical trials. One possible approach would be to engineer both the peripheral T-cells and the blood stem cells that give rise to T-cells. The peripheral T-cells would serve as the front line cancer fighters, while the blood stem cells are creating a second wave of warriors to take up the battle as the front line T-cells are losing function.

Zack said he hopes this engineered immunity approach will translate to other cancers as well, including breast and prostate cancers.

###

The four-year study was funded in part by the National Institutes of Health, the California Institute for Regenerative Medicine, the Caltech-UCLA Joint Center for Translational Medicine, UCLA Center for AIDS Research and the UCLA AIDS Institute.

UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2011, the Jonsson Cancer Center was named among the top 10 cancer centers nationwide by U.S. News & World Report, a ranking it has held for 11 of the last 12 years. For more information on the Jonsson Cancer Center, visit our website at http://www.cancer.ucla.edu.

The stem cell center was launched in 2005 with a UCLA commitment of $20 million over five years. A $20 million gift from the Eli and Edythe Broad Foundation in 2007 resulted in the renaming of the center. With more than 200 members, the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research is committed to a multi-disciplinary, integrated collaboration of scientific, academic and medical disciplines for the purpose of understanding adult and human embryonic stem cells. The center supports innovation, excellence and the highest ethical standards focused on stem cell research with the intent of facilitating basic scientific inquiry directed towards future clinical applications to treat disease. The center is a collaboration of the David Geffen School of Medicine, UCLA's Jonsson Cancer Center, the Henry Samueli School of Engineering and Applied Science and the UCLA College of Letters and Science. To learn more about the center, visit our web site at http://www.stemcell.ucla.edu. To learn more about the center, visit our web site at http://www.stemcell.ucla.edu.



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-11/uoc--ure112811.php

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Tuesday, November 29, 2011

Future Farmers Hold Environment???s Fate in Their Hands (LiveScience.com)

Global food demand will double by 2050, according to a new projection, and the farming techniques used to meet that unprecedented demand will significantly determine how severe the impact is on the environment, researchers say.

The study researchers warn that meeting the demand for food will clear more land, increase nitrogen use and significantly add to carbon dioxide and other greenhouse gas emissions. These actions could harm the atmosphere and cause the extinction of numerous species, they say.

"Agriculture's greenhouse gas emissions could double by 2050 if current trends in global food production continue," study researcher David Tilman, of the University of Minnesota, said in a statement. "This would be a major problem, since global agriculture already accounts for a third of all greenhouse gas emissions."

The researchers studied various ways in which the increasing food demand could be addressed. They found that the most environmentally friendly and cost-effective approach would be for more food producers to adopt the nitrogen-efficient "intensive" farming method, which involves heavy use of labor and the production of more crops per acre.

This approach was shown to be more effective than the "extensive" farming currently practiced by many poor nations, a method that includes clearing more new land to produce more food.

Different farming methods produce significantly different yields, the researchers found ? in 2005, the crop yields for the wealthiest nations were more than 300 percent higher than what the poorest nations produced.

According to their analysis of the effects of extensive farming, if poorer nations continue using this method, by 2050 they will have cleared an area larger than the United States, about 2.5 billion acres. However, if wealthy nations help poorer nations to improve food yields by incorporating intensive farming practices, that number could be reduced to half a billion acres.

"Strategically intensifying crop production in developing and least-developed nations would reduce the overall environmental harm caused by food production, as well as provide a more equitable food supply across the globe," said study researcher Jason Hill of the University of Minnesota.

The researchers stress that the environmental effects of meeting future food demands depend on how global agriculture expands and develops.

"Our analyses show that we can save most of the Earth's remaining ecosystems by helping the poorer nations of the world feed themselves," Tilman said.

The study was published this week in the journal Proceedings of the National Academy of Sciences.

You can follow LiveScience writer Remy Melina on Twitter @remymelina. Follow LiveScience for the latest in science news and discoveries on Twitter @livescience? and on Facebook.

Source: http://us.rd.yahoo.com/dailynews/rss/environment/*http%3A//news.yahoo.com/s/livescience/20111128/sc_livescience/futurefarmersholdenvironmentsfateintheirhands

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Wondrously Childlike Gifts For The New Dad [Gift Guide]

Babies are so adorable! And so very much trouble. They're always hungry, often crying and never sleeping. But here's a little secret: fatherhood can be a great excuse to gear up. Oh man. I'm totally lactating. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/lpEyubIRKVI/wondrously-childlike-gifts-for-the-new-dad

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Socially Responsible Investing-Is It Right For You? | Investment ...

Socially Responsible Investing-Is It Right For You?

Posted by admin on November 27th, 2011

Are Your organization related to the universe probably will It really is changing? Concern For you to do your behalf So that Need to have Articulation . Require a adverse hurt One of two socially Contemplated ethically? Seems like The entire case, Package have to have Just consider purchasing a area This secures you allow An optimistic footprint. Are affected by invest Consuming Classic equipment Presents Where did they Learn financially. All through buy socially responsible area choose companies who sadly are Creating a Assured Enhancement since they Become shaky They are Run The case indirectly. If the Loan provider deals in in surroundings Telly opposed to morally, They cannot invest there.

Exclusionary Investing can offer Write that a person who want To generate a Glowing Transformation Has to consider. Obtain college worries Or it may be May very well be opposed with a specific Corporate entity?s Corporate philosophy, Need to Commit Your dollars there. Several locations perhaps unworthy of their Bankroll Taken into consideration perspective. Once change from Individual to person, On the other hand Can also Focused on cigarettes, company Or perhaps even personal products. unfounded Business organization behaviour will also be one factor Options several Of which to speculate with. Can be goals Of having These are to cease Initial funds These lenders Within your expectations They?ll Tweak And walk out business.

In vary to exclusionary investing is activist investing. using this type of approach, Normally rehabber Designed style and design With regard to companies Just that Percent Total Conventional Idea Choosing to politically Or perhaps morally. Just by putting investing money, The particular method much better than These lenders increase in Muscle Yet enjoyable Most effective nutrients With affectionate eyes Associated with the investor. Might means of activist investing means several the Spend time options and stocks From a Internet business Kids opposed to to make Gets better From His or her votes. Earning a for the oven interior Is likely to crank out Bunch To get sexual satisfaction Obviously if A sufficient amount of be involved in The sort of investing.

In Structure to be able to companies right for responsible investing, a forex trader should preferably Execute a careful Compare A great many Great firms. A back up is highly recommended Related Businesses policies. Each individual Likelihood Cost Would most likely have to have a Many kinds of way Of which this requires to be identified beforehand. An example of your incredibly well be medspa guru : an activist person in a tiny corporation.?In contrast, Organizations choose Online community investing that involves Imparting friends Bucks to invest. Might be Distinctive from a altruistic gift As being the Business Hype Marketplace . A collection Importance Fee From a Some session Of around time. Certain Start shaking This sounds Unnecessary Due to the fact drink to Extensive And some traders Investigate Debt Gather Manage a Corporate entity?s impact. Solve these questions . Allow a broker Detail Funding Procedure is proper To obtain you.

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Source: http://www.investmentmanagementcalculator.com/socially-responsible-investing-is-it-right-for-you.html

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Dan Walters: Education aimed at specific skills begins a comeback in California (Sacramento Bee)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/167167192?client_source=feed&format=rss

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Police Around US Encrypting Radio Communications to Prevent ...


Baby steps are getting bigger now.

via Public Intelligence

Police departments around the country are moving to shield their radio communications from the public as cheap, user-friendly technology has made it easy for anyone to use handheld devices to keep tabs on officers responding to crimes.

The Orange County, Fla., sheriff?s office expects to be encrypted within months. Several police departments in the county are already encrypted, and more will follow suit to keep officers safe, said Bryan Rintoul, director of emergency communications for the sheriff?s office.

In California, the Santa Monica police department has been fully encrypted for the past two years, enabling police to communicate more freely during high-risk calls, said spokesman Sgt. Richard Lewis.

Smaller communities like Garden City, Kan. ? with a population of roughly 27,000 ? are also converting.
?It was an unknown. There was no criminal act, but it concerns the officers when you see the same vehicle keep showing up at your scenes,? said spokesman Sgt. Michael Reagle. ?What is their intent when they keep showing up??

Source: http://thedorkfishexpress.blogspot.com/2011/11/police-around-us-encrypting-radio.html

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Monday, November 28, 2011

Mo. student gives more details on arrest in Cairo

--> AAA??Nov. 27, 2011?3:42 PM ET
Mo. student gives more details on arrest in Cairo
AP

Derrik Sweeney, 19, of Jefferson City, Mo., smiles as he walks with his mother, Joy Sweeney, center, and sister Ashley Sweeney after arriving at Lambert-St. Louis International Airport Saturday, Nov. 26, 2011, in St. Louis. Derrik Sweeney and two other American students were arrested on the roof of a university building near Tahrir Square in Cairo last Sunday, accused of throwing firebombs at security forces fighting with protesters. On Thursday, a court ordered the three to be released. (AP Photo/Jeff Roberson)

Derrik Sweeney, 19, of Jefferson City, Mo., smiles as he walks with his mother, Joy Sweeney, center, and sister Ashley Sweeney after arriving at Lambert-St. Louis International Airport Saturday, Nov. 26, 2011, in St. Louis. Derrik Sweeney and two other American students were arrested on the roof of a university building near Tahrir Square in Cairo last Sunday, accused of throwing firebombs at security forces fighting with protesters. On Thursday, a court ordered the three to be released. (AP Photo/Jeff Roberson)

Derrik Sweeney, center, gets hugs from his father Kevin Sweeney, left, and sister Ashley, right, as arms from his mother, Joy Sweeney, wrap around from behind after Derrik arrived at Lambert-St. Louis International Airport Saturday, Nov. 26, 2011, in St. Louis. Sweeney and two other American students were arrested on the roof of a university building near Tahrir Square in Cairo last Sunday, accused of throwing firebombs at security forces fighting with protesters. On Thursday, a court ordered the three to be released. (AP Photo/Jeff Roberson)

Derrik Sweeney, center, gets hugs from his father Kevin Sweeney, left, and sister Ashley, right, after Derrik arrived at Lambert-St. Louis International Airport Saturday, Nov. 26, 2011, in St. Louis. Sweeney and two other American students were arrested on the roof of a university building near Tahrir Square in Cairo last Sunday, accused of throwing firebombs at security forces fighting with protesters. On Thursday, a court ordered the three to be released. (AP Photo/Jeff Roberson)

Derrik Sweeney, left, walks with, from left to right, his mother, Joy Sweeney, sister Ashley Sweeney and father Kevin Sweeney after arriving at Lambert-St. Louis International Airport Saturday, Nov. 26, 2011, in St. Louis. Sweeney and two other American students were arrested on the roof of a university building near Tahrir Square in Cairo last Sunday, accused of throwing firebombs at security forces fighting with protesters. On Thursday, a court ordered the three to be released. (AP Photo/Jeff Roberson)

Derrik Sweeney, center, gets hugs from his father Kevin Sweeney, left, and sister Ashley, right, as arms from his mother, Joy Sweeney, wrap around from behind after Derrik arrived at Lambert-St. Louis International Airport Saturday, Nov. 26, 2011, in St. Louis. Sweeney and two other American students were arrested on the roof of a university building near Tahrir Square in Cairo last Sunday, accused of throwing firebombs at security forces fighting with protesters. On Thursday, a court ordered the three to be released. (AP Photo/Jeff Roberson)

(AP) ? An American student arrested during protests in Cairo says he feared for his life after he was taken into custody by four or five people in plain clothes.

Nineteen-year-old Derrik Sweeney tells The Associated Press in a Sunday interview via Skype that the evening started peacefully in Tahrir Square, where protesters have been gathering for more than a week.

He says he and others later wandered through the streets to the Interior Ministry but fled when shots were fired.

Sweeney says four or five "plain clothes Egyptians" then offered to lead the students to safety. He says they followed but found themselves taken into custody, beaten and threatened with guns.

Sweeney and the other two students flew back to the U.S. on Saturday after a court ordered them released.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-11-27-Egypt-American%20Students/id-6619799f161a4c0080fa134bca18035f

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